Fig. 6

Effects of crocetin and cisplatin on MAPK pathways in KYSE-150 cells. The expression levels of p-ERK1/2, ERK1/2, p-p38, p38, p-JNK, and JNK in KYSE-150 cells were untreated (control), or treated with 200 μmol/L of crocetin, 2 μg/L of cisplatin (DDP), and 200 μmol/L of crocetin + 2 μg/L of cisplatin (C + D) for 48 h, as determined by Western blot analysis. GAPDH was used as a loading control. *p < 0.05 compared with the control group; ^#p < 0.05 compared with the combined crocetin and cisplatin group