MicroRNA-214-3p inhibits proliferation and cell cycle progression by targeting MELK in hepatocellular carcinoma and correlates cancer prognosis

Table 1 Clinicopathology parameters in 98 HCC patients according to high- or low miR-214-3p expression level

Parameter	n	Low miR-214-3p expression	High miR-214-3p expression	P
Age	98	56.60 ± 6.14	54.06 ± 8.73	0.327^*
Gender
Male	83	44	39	0.742^#
Female	15	6	9
Liver disease
HBV	93	46	47	1.000^∆
Others	5	3	2
Cirrhosis
Positive	94	46	48	1.000^∆
Negative	4	2	2
Tumor stage
I + II	65	32	33	0.791^#
III	33	18	15
Histologic grade
Differentiated	87	41	46	0.068^∆
Undifferentiated	11	8	3
Milan criteria
In	53	23	30	0.163^#
Out	45	26	19
Tumor size (cm)
≤ 4.5	59	24	35	0.016^#
> 4.5	39	25	14
Multinodular
Positive	43	25	18	0.044^#
Negative	55	24	31
Vascular invasion
Positive	22	16	6	0.025^#
Negative	77	33	43
Serum AFP (ng/ml)
≤ 400	62	29	33	1.000^#
> 400	36	19	17
Overall survival	41/98	11/49	30/49
HCC recurrence	57/98	37/49	20/49

ISSN: 1475-2867