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Table 1 Clinicopathology parameters in 98 HCC patients according to high- or low miR-214-3p expression level

From: MicroRNA-214-3p inhibits proliferation and cell cycle progression by targeting MELK in hepatocellular carcinoma and correlates cancer prognosis

Parameter n Low miR-214-3p expression High miR-214-3p expression P
Age 98 56.60 ± 6.14 54.06 ± 8.73 0.327*
Gender
 Male 83 44 39 0.742#
 Female 15 6 9  
Liver disease
 HBV 93 46 47 1.000
 Others 5 3 2  
Cirrhosis
 Positive 94 46 48 1.000
 Negative 4 2 2  
Tumor stage
 I + II 65 32 33 0.791#
 III 33 18 15  
Histologic grade
 Differentiated 87 41 46 0.068
 Undifferentiated 11 8 3  
Milan criteria
 In 53 23 30 0.163#
 Out 45 26 19  
Tumor size (cm)
 ≤ 4.5 59 24 35 0.016#
 > 4.5 39 25 14  
Multinodular
 Positive 43 25 18 0.044#
 Negative 55 24 31  
Vascular invasion
 Positive 22 16 6 0.025#
 Negative 77 33 43  
Serum AFP (ng/ml)
 ≤ 400 62 29 33 1.000#
 > 400 36 19 17  
 Overall survival 41/98 11/49 30/49  
 HCC recurrence 57/98 37/49 20/49  
  1. AFP alpha-fetoprotein
  2. * Unpaired student t-test; #Chi square test; Fisher’s exact test