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Table 1 The effect of deubiquitinating enzymes in the regulation of target proteins

From: Targeting deubiquitinating enzymes in cancer stem cells

Proteins Deubiquitinating enzymes Effect References
Sox2 USP22 Transcription [15]
USP9X Unclear [16]
c-myc USP37 Protein stabilization [18]
USP22 [19]
USP36 [20]
USP28 [21]
Nanog USP21 Protein stabilization [22]
ID proteins USP1 Protein stabilization [24, 25]
SIRT1 USP22 Protein stabilization [30]
p53 USP10 Protein stabilization [33]
Ataxin-3 [34]
USP7 [35, 36]
OTUD1 [37]
OTUD5 [38]
USP11 [39]
PTEN ATXN3 Transcription [44]
USP18 Protein stabilization [45]
USP7 Location [46, 47]
PRC1 USP7 Protein stabilization [52]
USP11 [53]
USP26 [77]
PRC2 BAP1 Unclear [54]
LSD1 USP7 Protein stabilization [57]
USP28 [9]
HIF-1α USP8 Protein stabilization [66]
USP19 [65]
USP28 [64]
USP52 mRNA degradation [67]
IL-8 USP21 Transcription [79]
TRAF6 USP4 Activity [81]
A20 [82]