Targeting deubiquitinating enzymes in cancer stem cells

Table 1 The effect of deubiquitinating enzymes in the regulation of target proteins

Proteins	Deubiquitinating enzymes	Effect	References
Sox2	USP22	Transcription	[15]
Sox2	USP9X	Unclear	[16]
c-myc	USP37	Protein stabilization	[18]
	USP22		[19]
	USP36		[20]
	USP28		[21]
Nanog	USP21	Protein stabilization	[22]
ID proteins	USP1	Protein stabilization	[24, 25]
SIRT1	USP22	Protein stabilization	[30]
p53	USP10	Protein stabilization	[33]
	Ataxin-3		[34]
	USP7		[35, 36]
	OTUD1		[37]
	OTUD5		[38]
	USP11		[39]
PTEN	ATXN3	Transcription	[44]
	USP18	Protein stabilization	[45]
	USP7	Location	[46, 47]
PRC1	USP7	Protein stabilization	[52]
	USP11		[53]
	USP26		[77]
PRC2	BAP1	Unclear	[54]
LSD1	USP7	Protein stabilization	[57]
LSD1	USP28	Protein stabilization	[9]
HIF-1α	USP8	Protein stabilization	[66]
	USP19		[65]
	USP28		[64]
	USP52	mRNA degradation	[67]
IL-8	USP21	Transcription	[79]
TRAF6	USP4	Activity	[81]
TRAF6	A20	Activity	[82]

ISSN: 1475-2867