Targeting deubiquitinating enzymes in cancer stem cells

Table 2 DUB inhibitors for preclinical application in CSC-targeted therapy

Inhibitors	Targeted DUBs	CSC type	References
Pimozide	USP1	Osteosarcoma, glioblastoma	[25, 83]
ML323	USP1	Osteosarcoma, glioblastoma	[25, 83]
P5091	USP7, USP47	Neural, glioblastoma, multiple myeloma	[57, 85–87]
P22077	USP7, USP47	Neural, glioblastoma, multiple myeloma	[57, 85–87]
WP1130	USP9x, USP5, UCHL1, USP14, UCH37	Liver, breast cancer	[72, 73]
IU1	USP14	Gastric, multiple myeloma	[74, 75]
b-AP15	USP14, UCHL5
VLX1570	USP14
LDN-57444	UCHL1, UCHL3	Prostate	[76]
TCID	UCHL3, UCHL5	Multiple myeloma	[84]

ISSN: 1475-2867