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Table 1 A total of 76 differentially expressed microRNAs with significantly lower expression in glioblastoma (GBM) compared to non-tumour brain tissues

From: Restoration of miR-29b exerts anti-cancer effects on glioblastoma

No. MicroRNA log2(FC) log2(FC-standard error) z-statistic p value FDR
1 hsa-miR-124 7.5068 1.0387 7.2270 0.0000 0.0000
2 hsa-miR-218 6.6782 0.9775 6.8322 0.0000 0.0000
3 hsa-miR-873 5.4139 1.0405 5.2031 0.0000 0.0000
4 hsa-miR-7 4.7696 0.7774 6.1350 0.0000 0.0000
5 hsa-miR-1912 4.5089 1.8598 2.4243 0.0153 0.0429
6 hsa-miR-129star 4.5065 0.7294 6.1782 0.0000 0.0000
7 hsa-miR-139-3p 4.3718 0.8802 4.9666 0.0000 0.0000
8 hsa-miR-383 4.1483 1.0614 3.9083 0.0001 0.0007
9 hsa-miR-495 4.0638 0.9937 4.0894 0.0000 0.0004
10 hsa-miR-139-5p 3.8873 0.9888 3.9314 0.0001 0.0007
11 hsa-miR-138 3.7940 0.8260 4.5930 0.0000 0.0001
12 hsa-miR-485-5p 3.6911 0.7200 5.1262 0.0000 0.0000
13 hsa-miR-323-3p 3.5294 0.6566 5.3754 0.0000 0.0000
14 hsa-miR-487b 3.5207 0.7118 4.9464 0.0000 0.0000
15 hsa-miR-485-3p 3.4738 0.7005 4.9591 0.0000 0.0000
16 hsa-miR-1286 3.4257 0.9717 3.5256 0.0004 0.0025
17 hsa-miR-1224-5p 3.3436 0.7768 4.3045 0.0000 0.0002
18 hsa-miR-132 3.3423 0.6392 5.2287 0.0000 0.0000
19 hsa-miR-543 3.2264 0.6293 5.1272 0.0000 0.0000
20 hsa-miR-490-3p 3.1761 0.7582 4.1889 0.0000 0.0003
21 hsa-miR-490-5p 3.1672 0.8236 3.8454 0.0001 0.0009
22 hsa-miR-410 3.0772 0.8013 3.8405 0.0001 0.0009
23 hsa-miR-668 3.0100 0.7603 3.9588 0.0001 0.0006
24 hsa-miR-323b-3p 2.9812 0.8378 3.5582 0.0004 0.0023
25 hsa-miR-212 2.8464 0.6536 4.3552 0.0000 0.0002
26 hsa-miR-628-5p 2.8262 0.5173 5.4638 0.0000 0.0000
27 hsa-miR-124star 2.8005 0.8573 3.2666 0.0011 0.0055
28 hsa-miR-136 2.7895 0.7544 3.6977 0.0002 0.0014
29 hsa-miR-935 2.7497 0.7178 3.8304 0.0001 0.0009
30 hsa-miR-539 2.7319 0.9807 2.7857 0.0053 0.0194
31 hsa-miR-504 2.7238 0.8304 3.2800 0.0010 0.0053
32 hsa-miR-487a 2.7167 0.7557 3.5948 0.0003 0.0021
33 hsa-miR-138-1star 2.6958 0.5442 4.9533 0.0000 0.0000
34 hsa-miR-132star 2.6106 0.8890 2.9365 0.0033 0.0145
35 hsa-miR-770-5p 2.5856 0.9006 2.8711 0.0041 0.0165
36 hsa-miR-433 2.5657 1.0518 2.4394 0.0147 0.0415
37 hsa-miR-4446-3p 2.5107 0.9984 2.5147 0.0119 0.0351
38 hsa-miR-154star 2.5037 0.6443 3.8859 0.0001 0.0008
39 hsa-miR-375 2.4955 0.7418 3.3642 0.0008 0.0042
40 hsa-miR-431star 2.4278 0.8736 2.7791 0.0055 0.0196
41 hsa-miR-411star 2.3678 0.5828 4.0629 0.0000 0.0004
42 hsa-miR-342-3p 2.3513 0.6636 3.5430 0.0004 0.0024
43 hsa-miR-376astar 2.3385 0.8987 2.6022 0.0093 0.0293
44 hsa-miR-431 2.3223 1.1063 2.0991 0.0358 0.0851
45 hsa-miR-496 2.2728 0.8521 2.6672 0.0076 0.0254
46 hsa-miR-7-1star 2.1583 0.8207 2.6299 0.0085 0.0274
47 hsa-miR-769-3p 2.1347 0.5331 4.0047 0.0001 0.0005
48 hsa-miR-655 2.0954 0.9282 2.2574 0.0240 0.0606
49 hsa-miR-432 2.0845 0.7328 2.8443 0.0045 0.0175
50 hsa-miR-203 2.0536 0.7244 2.8349 0.0046 0.0175
51 hsa-miR-382 2.0529 0.7358 2.7901 0.0053 0.0193
52 hsa-miR-329 2.0327 0.8035 2.5298 0.0114 0.0344
53 hsa-miR-491-5p 2.0173 0.7588 2.6586 0.0078 0.0257
54 hsa-miR-221 1.9337 0.6314 3.0623 0.0022 0.0102
55 hsa-miR-379 1.9324 0.7444 2.5961 0.0094 0.0296
56 hsa-miR-369-5p 1.8083 0.7021 2.5755 0.0100 0.0307
57 hsa-miR-330-3p 1.8050 0.6517 2.7699 0.0056 0.0199
58 hsa-miR-379star 1.7531 0.7448 2.3540 0.0186 0.0502
59 hsa-miR-149 1.7529 0.6027 2.9083 0.0036 0.0153
60 hsa-miR-1 1.7498 0.4676 3.7418 0.0002 0.0012
61 hsa-miR-889 1.7203 0.7117 2.4174 0.0156 0.0435
62 hsa-miR-136star 1.6970 0.6581 2.5789 0.0099 0.0306
63 hsa-miR-153 1.5730 0.6368 2.4703 0.0135 0.0392
64 hsa-miR-766 1.5411 0.6396 2.4093 0.0160 0.0438
65 hsa-miR-377star 1.4851 0.6731 2.2063 0.0274 0.0678
66 hsa-miR-411 1.4768 0.6314 2.3389 0.0193 0.0513
67 hsa-miR-377 1.4701 0.6668 2.2046 0.0275 0.0678
68 hsa-miR-95 1.4609 0.6567 2.2247 0.0261 0.0656
69 hsa-miR-376a 1.4324 0.7042 2.0342 0.0419 0.0972
70 hsa-miR-127-5p 1.3517 0.6337 2.1329 0.0329 0.0787
71 hsa-miR-29b 1.3389 0.5925 2.2597 0.0238 0.0606
72 hsa-miR-425 1.3189 0.6458 2.0421 0.0411 0.0960
73 hsa-let-7d 1.2599 0.5884 2.1411 0.0323 0.0776
74 hsa-miR-191 1.1826 0.4351 2.7181 0.0066 0.0222
75 hsa-miR-598 1.1699 0.5339 2.1911 0.0284 0.0697
76 hsa-miR-769-5p 1.1113 0.4806 2.3121 0.0208 0.0543
  1. Whole set of differentially expressed microRNAs between GBM and non-tumor brain tissues are listed in Additional file 1: Table S2. A total of 170 microRNAs were found to be significant after combining open source data from two previous studies comparing GBM (n = 9) and non-tumour brain tissues (n = 6) with miRNA-seq [13, 14]. Log2(FC) indicates log2(fold change of non-tumour brain tissues to GBM)