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Table 1 A total of 76 differentially expressed microRNAs with significantly lower expression in glioblastoma (GBM) compared to non-tumour brain tissues

From: Restoration of miR-29b exerts anti-cancer effects on glioblastoma

No.

MicroRNA

log2(FC)

log2(FC-standard error)

z-statistic

p value

FDR

1

hsa-miR-124

7.5068

1.0387

7.2270

0.0000

0.0000

2

hsa-miR-218

6.6782

0.9775

6.8322

0.0000

0.0000

3

hsa-miR-873

5.4139

1.0405

5.2031

0.0000

0.0000

4

hsa-miR-7

4.7696

0.7774

6.1350

0.0000

0.0000

5

hsa-miR-1912

4.5089

1.8598

2.4243

0.0153

0.0429

6

hsa-miR-129star

4.5065

0.7294

6.1782

0.0000

0.0000

7

hsa-miR-139-3p

4.3718

0.8802

4.9666

0.0000

0.0000

8

hsa-miR-383

4.1483

1.0614

3.9083

0.0001

0.0007

9

hsa-miR-495

4.0638

0.9937

4.0894

0.0000

0.0004

10

hsa-miR-139-5p

3.8873

0.9888

3.9314

0.0001

0.0007

11

hsa-miR-138

3.7940

0.8260

4.5930

0.0000

0.0001

12

hsa-miR-485-5p

3.6911

0.7200

5.1262

0.0000

0.0000

13

hsa-miR-323-3p

3.5294

0.6566

5.3754

0.0000

0.0000

14

hsa-miR-487b

3.5207

0.7118

4.9464

0.0000

0.0000

15

hsa-miR-485-3p

3.4738

0.7005

4.9591

0.0000

0.0000

16

hsa-miR-1286

3.4257

0.9717

3.5256

0.0004

0.0025

17

hsa-miR-1224-5p

3.3436

0.7768

4.3045

0.0000

0.0002

18

hsa-miR-132

3.3423

0.6392

5.2287

0.0000

0.0000

19

hsa-miR-543

3.2264

0.6293

5.1272

0.0000

0.0000

20

hsa-miR-490-3p

3.1761

0.7582

4.1889

0.0000

0.0003

21

hsa-miR-490-5p

3.1672

0.8236

3.8454

0.0001

0.0009

22

hsa-miR-410

3.0772

0.8013

3.8405

0.0001

0.0009

23

hsa-miR-668

3.0100

0.7603

3.9588

0.0001

0.0006

24

hsa-miR-323b-3p

2.9812

0.8378

3.5582

0.0004

0.0023

25

hsa-miR-212

2.8464

0.6536

4.3552

0.0000

0.0002

26

hsa-miR-628-5p

2.8262

0.5173

5.4638

0.0000

0.0000

27

hsa-miR-124star

2.8005

0.8573

3.2666

0.0011

0.0055

28

hsa-miR-136

2.7895

0.7544

3.6977

0.0002

0.0014

29

hsa-miR-935

2.7497

0.7178

3.8304

0.0001

0.0009

30

hsa-miR-539

2.7319

0.9807

2.7857

0.0053

0.0194

31

hsa-miR-504

2.7238

0.8304

3.2800

0.0010

0.0053

32

hsa-miR-487a

2.7167

0.7557

3.5948

0.0003

0.0021

33

hsa-miR-138-1star

2.6958

0.5442

4.9533

0.0000

0.0000

34

hsa-miR-132star

2.6106

0.8890

2.9365

0.0033

0.0145

35

hsa-miR-770-5p

2.5856

0.9006

2.8711

0.0041

0.0165

36

hsa-miR-433

2.5657

1.0518

2.4394

0.0147

0.0415

37

hsa-miR-4446-3p

2.5107

0.9984

2.5147

0.0119

0.0351

38

hsa-miR-154star

2.5037

0.6443

3.8859

0.0001

0.0008

39

hsa-miR-375

2.4955

0.7418

3.3642

0.0008

0.0042

40

hsa-miR-431star

2.4278

0.8736

2.7791

0.0055

0.0196

41

hsa-miR-411star

2.3678

0.5828

4.0629

0.0000

0.0004

42

hsa-miR-342-3p

2.3513

0.6636

3.5430

0.0004

0.0024

43

hsa-miR-376astar

2.3385

0.8987

2.6022

0.0093

0.0293

44

hsa-miR-431

2.3223

1.1063

2.0991

0.0358

0.0851

45

hsa-miR-496

2.2728

0.8521

2.6672

0.0076

0.0254

46

hsa-miR-7-1star

2.1583

0.8207

2.6299

0.0085

0.0274

47

hsa-miR-769-3p

2.1347

0.5331

4.0047

0.0001

0.0005

48

hsa-miR-655

2.0954

0.9282

2.2574

0.0240

0.0606

49

hsa-miR-432

2.0845

0.7328

2.8443

0.0045

0.0175

50

hsa-miR-203

2.0536

0.7244

2.8349

0.0046

0.0175

51

hsa-miR-382

2.0529

0.7358

2.7901

0.0053

0.0193

52

hsa-miR-329

2.0327

0.8035

2.5298

0.0114

0.0344

53

hsa-miR-491-5p

2.0173

0.7588

2.6586

0.0078

0.0257

54

hsa-miR-221

1.9337

0.6314

3.0623

0.0022

0.0102

55

hsa-miR-379

1.9324

0.7444

2.5961

0.0094

0.0296

56

hsa-miR-369-5p

1.8083

0.7021

2.5755

0.0100

0.0307

57

hsa-miR-330-3p

1.8050

0.6517

2.7699

0.0056

0.0199

58

hsa-miR-379star

1.7531

0.7448

2.3540

0.0186

0.0502

59

hsa-miR-149

1.7529

0.6027

2.9083

0.0036

0.0153

60

hsa-miR-1

1.7498

0.4676

3.7418

0.0002

0.0012

61

hsa-miR-889

1.7203

0.7117

2.4174

0.0156

0.0435

62

hsa-miR-136star

1.6970

0.6581

2.5789

0.0099

0.0306

63

hsa-miR-153

1.5730

0.6368

2.4703

0.0135

0.0392

64

hsa-miR-766

1.5411

0.6396

2.4093

0.0160

0.0438

65

hsa-miR-377star

1.4851

0.6731

2.2063

0.0274

0.0678

66

hsa-miR-411

1.4768

0.6314

2.3389

0.0193

0.0513

67

hsa-miR-377

1.4701

0.6668

2.2046

0.0275

0.0678

68

hsa-miR-95

1.4609

0.6567

2.2247

0.0261

0.0656

69

hsa-miR-376a

1.4324

0.7042

2.0342

0.0419

0.0972

70

hsa-miR-127-5p

1.3517

0.6337

2.1329

0.0329

0.0787

71

hsa-miR-29b

1.3389

0.5925

2.2597

0.0238

0.0606

72

hsa-miR-425

1.3189

0.6458

2.0421

0.0411

0.0960

73

hsa-let-7d

1.2599

0.5884

2.1411

0.0323

0.0776

74

hsa-miR-191

1.1826

0.4351

2.7181

0.0066

0.0222

75

hsa-miR-598

1.1699

0.5339

2.1911

0.0284

0.0697

76

hsa-miR-769-5p

1.1113

0.4806

2.3121

0.0208

0.0543

  1. Whole set of differentially expressed microRNAs between GBM and non-tumor brain tissues are listed in Additional file 1: Table S2. A total of 170 microRNAs were found to be significant after combining open source data from two previous studies comparing GBM (n = 9) and non-tumour brain tissues (n = 6) with miRNA-seq [13, 14]. Log2(FC) indicates log2(fold change of non-tumour brain tissues to GBM)
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Cancer Cell International

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