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Fig. 4 | Cancer Cell International

Fig. 4

From: Pharmacological inhibition of Bmi1 by PTC-209 impaired tumor growth in head neck squamous cell carcinoma

Fig. 4

PTC-209 inhibited cell migration and invasion of HNSCC cells. a Cell migration was significantly reduced in cells treated with PTC-209 (10 μM, 24 h) as measured in wound healing assay. Scale bar: 200 μm. b Cell invasiveness was pronouncedly impaired in cells treated with PTC-209 (10 μM, 24 h) as measured in the transwell assay. Scale bar: 50 μm. c The amount of E-cadherin was increased and N-cadherin and vimentin was downregulated simultaneously in cells treated with PTC-209 (10 μM, 48 h). Representative images are shown. Data showed here are mean ± SD from three independent experiments

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