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Table 2 Cytotoxic effects of 5-fluorouracil and oxaliplatin against colorectal cancer cell lines

From: RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition

  FUra Oxa
IC50 μM (CI95) % top inhibition (CI95) IC50 μM (CI95) % top inhibition (CI95)
HT-29 N.A. N.A. 0.8 (0.6–1.0) 34% (31–36)
LoVo 0.6 (0.4–0.9) 80% (75–86) 0.05 (0.02–0.1) 33% (29–36)
LoVo control 0.6 (0.4–0.7) 82% (79–84) 0.04 (0.01–0.1) 30% (26–34)
LoVo RAC3 2.0 (1.4–2.8) 48% (45–51) 0.4 (0.25–0.6) 50% (46–53)
HCT 116 wt 4.5 (3.9–5.1) 75% (71–78) 0.6 (0.4–0.9) 36% (30–38)
HCT 116 control 4.2 (3.3–5.3) 78% (74–81) 0.6 (0.45–0.85) 42% (38–45)
HCT 116 shRAC3 2.4 (2.1–3.0) 88% (84–91) 0.17 (0.05–0.5) 52% (43–61)
  1. Values represent results from at least three independent experiments