Table 2 Cytotoxic effects of 5-fluorouracil and oxaliplatin against colorectal cancer cell lines
From: RAC3 influences the chemoresistance of colon cancer cells through autophagy and apoptosis inhibition
FUra | Oxa | |||
|---|---|---|---|---|
IC50 μM (CI95) | % top inhibition (CI95) | IC50 μM (CI95) | % top inhibition (CI95) | |
HT-29 | N.A. | N.A. | 0.8 (0.6–1.0) | 34% (31–36) |
LoVo | 0.6 (0.4–0.9) | 80% (75–86) | 0.05 (0.02–0.1) | 33% (29–36) |
LoVo control | 0.6 (0.4–0.7) | 82% (79–84) | 0.04 (0.01–0.1) | 30% (26–34) |
LoVo RAC3 | 2.0 (1.4–2.8) | 48% (45–51) | 0.4 (0.25–0.6) | 50% (46–53) |
HCT 116 wt | 4.5 (3.9–5.1) | 75% (71–78) | 0.6 (0.4–0.9) | 36% (30–38) |
HCT 116 control | 4.2 (3.3–5.3) | 78% (74–81) | 0.6 (0.45–0.85) | 42% (38–45) |
HCT 116 shRAC3 | 2.4 (2.1–3.0) | 88% (84–91) | 0.17 (0.05–0.5) | 52% (43–61) |