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Fig. 4 | Cancer Cell International

Fig. 4

From: Tumor-infiltrating CD4+ T cells in patients with gastric cancer

Fig. 4

Effect of PD-1+ and/or Tim-3+ blockade on IFN-γ-producing CD4+ and CD8+ T-cells from tumor tissues. a Data were displayed as FMO-corrected values with subtraction of the individual co-stimulated control sample. IFN-γ staining showed TILs cytokine secretion following anti-CD3 stimulation and in the presence of blocking antibodies. b Dot plot graphs showing the increase of IFN-γ secretion of CD4+ T-cells from isotype control antibody to a PD-1+and/or a Tim-3+. c Dot plot graphs showing the increase of IFN-γ secretion of CD8+ T-cells from isotype control antibody to a PD-1+ and/or a Tim-3+. p values were calculated by using paired t test

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