Fig. 5
From: Tumor-infiltrating CD4+ T cells in patients with gastric cancer
Elevated levels of tumor-infiltrating Tim-3+ PD-1+ CD4+/CD8+ T-cells in GC patients correlated with clinical stage. A significantly higher percentage of tumor-infiltrating Tim-3+ PD-1+ CD4+ (a) Tim-3+ PD-1+ CD8+ (b) T-cells were observed in cancer patients with stage III GC relative to stage I/II. Scatter plots of Tim-3+ PD-1+ among CD4+ (c) and CD8+ (d) T-cells percentage in well/moderate vs. poor differentiation patients. Percentage of tumor-infiltrating Tim-3+ PD-1+ CD4+/CD8+ T-cells from all patients were analyzed to correlate with the serum concentration (before treatment) of cancer biomarker CEA (e for CD4+, f for CD8+), and CA724 (g for CD4+, h for CD8+). Unparametric spearman correlation analysis was performed by GraphPad software. Bar denotes median in each group. p < 0.05 was considered as statistically significant