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Fig. 6 | Cancer Cell International

Fig. 6

From: SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer

Fig. 6

Effect of SHP-2 on clearance of damaged mitochondria. a Confocal microscopy of Hela cells transfected SHP-2 shRNA1 or treated CCCP (10 μM), immunostained for p62 (green) and Tom20 (red). b Confocal microscopy of GFP-LC3 + Hela cells transfected SHP-2 shRNA1 or treated CCCP (10 μM), immunostained for endogenous Tom20. c, d Subcellular distribution of p62, LC3-II, and Parkin a transfected SHP-2 shRNA1 or treated CCCP (10 μM). Data are presented as mean ± SD. **P < 0.01 compared with CCCP treatment group. Data are representative of at least three experiments

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