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Fig. 7 | Cancer Cell International

Fig. 7

From: SHP-2 restricts apoptosis induced by chemotherapeutic agents via Parkin-dependent autophagy in cervical cancer

Fig. 7

The clearance of damaged mitochondria is Parkin-dependent. a Confocal microscopy of Hela cells transfected SHP-2 shRNA1 or treated CCCP (10 μM), immunostained for Parkin (green) and Tom20 (red). b Confocal microscopy of C33A cells transfected Parkin shRNA or pCMV-SHP2-HA plasmid, immunostained for p62 (green) and Tom20 (red). c Confocal microscopy of C33A cells transfected Parkin shRNA or pCMV-SHP2-HA plasmid, immunostained for Poly-Ub (green) and Tom20 (red). Data are representative of at least three experiments

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