Fig. 5From: Down regulation of G protein-coupled receptor 137 expression inhibits proliferation and promotes apoptosis in leukemia cellsRepresentative flow cytometric histograms of distribution of cell cycles of K562 (a) and HL60 (b). down regulation of GPR137 leads the cell-cycle arrested at G0/G1 phase of cell cycle in both cell lines. Percentages of K562 (c) and HL60 (d) cells at G0/G1, S, G2/M phase were shown. There was a significant difference between cells transduced with control lentiviral vector (Lv-shCon) and cells transduced with lentiviral vector expressing GPR137 (LvshGPR137) (P < 0.05). The expression of CyclinD1 and CDK4 were reduced in K562 (e) and HL60 (f) cells. Lane 1: nontransduced cells and lane 2: cells transduced with lentiviral vector expressing shGPRBack to article page