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Fig. 5 | Cancer Cell International

Fig. 5

From: Down regulation of G protein-coupled receptor 137 expression inhibits proliferation and promotes apoptosis in leukemia cells

Fig. 5

Representative flow cytometric histograms of distribution of cell cycles of K562 (a) and HL60 (b). down regulation of GPR137 leads the cell-cycle arrested at G0/G1 phase of cell cycle in both cell lines. Percentages of K562 (c) and HL60 (d) cells at G0/G1, S, G2/M phase were shown. There was a significant difference between cells transduced with control lentiviral vector (Lv-shCon) and cells transduced with lentiviral vector expressing GPR137 (LvshGPR137) (P < 0.05). The expression of CyclinD1 and CDK4 were reduced in K562 (e) and HL60 (f) cells. Lane 1: nontransduced cells and lane 2: cells transduced with lentiviral vector expressing shGPR

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