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Fig. 5 | Cancer Cell International

Fig. 5

From: Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

Fig. 5

Effect of the domain mutations on the expression levels of p53 regulated glycolytic enzymes. qPCR for the p53 downregulated glycolytic enzymes aldolase, G6PDH, GLUT1 and 3, PFK and PK, and the p53 upregulated proteins PDHa and TIGAR was performed using the cDNA of the 3 ovarian cancer cell lines (a), the tumor cultured cells (b) and the transfected SK-OV-3 cells (c). Each value represents the mean of 3 assays. The control was set to 1, and the values are compared to the control. The results are displayed as the mean ± SD. *P < 0.05 versus the control, and **P < 0.01 versus the control

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