Fig. 6

Caspase-8 activation attenuates cell death. MDA-MB 231 cells were incubated with 5 mM MβCD in the presence and absence of mitomycin c (60 µg/ml) (a, b) and cycloheximide (c) for 6 h. Cell viability and mitochondrial membrane potential was measured by flow cytometer. Schematic diagram of caspase-8 and promotion of autophagy in lipid raft disruption (d). Statistical analysis: One way anova, post hock test Tukey. *P < 0.05, **P < 0.01, **P < 0.001, N.S. not significant