Table 2 E2 targeted genes from RT2 Profiler™ PCR array human tumor metastasis compared between E2-treated KKU-213 and untreated control
Genes | Full name | Fold change |
|---|---|---|
Up-regulated gene | ||
 ITG B3 | Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 15.81 |
 MET | Met proto-oncogene (hepatocyte growth factor receptor) | 7.38 |
 MMP11 | Matrix metallopeptidase 11 (stromelysin 3) | 6.27 |
 HPSE | Heparanase | 5.87 |
 HRAS | V-Ha-ras Harvey rat sarcoma viral oncogene homolog | 5.36 |
 SYK | Spleen tyrosine kinase | 4.49 |
 IL18 | Interleukin 18 (interferon-gamma-inducing factor) | 4.16 |
 CXCR4 | Chemokine (C-X-C motif) receptor 4 | 3.98 |
 RPSA | Ribosomal protein SA | 3.43 |
 IL1B | Interleukin 1, beta | 3.32 |
 FGFR4 | Fibroblast growth factor receptor 4 | 2.89 |
 DENR | Density-regulated protein | 2.56 |
 ETV4 | ETS variant 4 | 2.49 |
 MMP10 | Matrix metallopeptidase 10 (stromelysin 2) | 2.16 |
Down-regulated gene | ||
 CTBP1 | C-terminal binding protein 1 | 0.42 |
 RORB | RAR-related orphan receptor B | 0.41 |
 FAT | FAT tumor suppressor homolog 1 (Drosophila) | 0.39 |
 BRMS1 | Breast cancer metastasis suppressor 1 | 0.34 |
 CST7 | Cystatin F (leukocystatin) | 0.24 |
 CD82 | CD82 molecule | 0.20 |
 TNFS10 | Tumor necrosis factor (ligand) superfamily, member 10 | 0.16 |
 RB1 | Retinoblastoma 1 (including osteosarcoma) | 0.13 |
 TRPM1 | Transient receptor potential cation channel, subfamily M, member 1 | 0.12 |