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Table 2 E2 targeted genes from RT2 Profiler™ PCR array human tumor metastasis compared between E2-treated KKU-213 and untreated control

From: Increased ETV4 expression correlates with estrogen-enhanced proliferation and invasiveness of cholangiocarcinoma cells

Genes Full name Fold change
Up-regulated gene
 ITG B3 Integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 15.81
 MET Met proto-oncogene (hepatocyte growth factor receptor) 7.38
 MMP11 Matrix metallopeptidase 11 (stromelysin 3) 6.27
 HPSE Heparanase 5.87
 HRAS V-Ha-ras Harvey rat sarcoma viral oncogene homolog 5.36
 SYK Spleen tyrosine kinase 4.49
 IL18 Interleukin 18 (interferon-gamma-inducing factor) 4.16
 CXCR4 Chemokine (C-X-C motif) receptor 4 3.98
 RPSA Ribosomal protein SA 3.43
 IL1B Interleukin 1, beta 3.32
 FGFR4 Fibroblast growth factor receptor 4 2.89
 DENR Density-regulated protein 2.56
 ETV4 ETS variant 4 2.49
 MMP10 Matrix metallopeptidase 10 (stromelysin 2) 2.16
Down-regulated gene
 CTBP1 C-terminal binding protein 1 0.42
 RORB RAR-related orphan receptor B 0.41
 FAT FAT tumor suppressor homolog 1 (Drosophila) 0.39
 BRMS1 Breast cancer metastasis suppressor 1 0.34
 CST7 Cystatin F (leukocystatin) 0.24
 CD82 CD82 molecule 0.20
 TNFS10 Tumor necrosis factor (ligand) superfamily, member 10 0.16
 RB1 Retinoblastoma 1 (including osteosarcoma) 0.13
 TRPM1 Transient receptor potential cation channel, subfamily M, member 1 0.12
  1. Among a total of 84 genes analyzed, the relative expression of 14 genes was up-regulated (by more than twofold) in response to estrogen, while 9 genes were downregulated (by less than 0.5-fold)