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Fig. 10 | Cancer Cell International

Fig. 10

From: The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cells

Fig. 10

Relative protein expression of phosphorylated and total ERK1/2 (a) and phosphorylated SAPK (b) in H295R cells. (−) treated with DMSO or (+) 10 μM Nilotinib for 15 and 60 min. The results are expressed as the mean ± SD. Paired t test, n = 3. Relative protein expression of phosphorylated and total ERK1/2 in H295R cells (−) treated with DMSO or (+) 10 μM U0126 for 60 min or/and (+) Nilotinib for 60 min (c). Cell viability analysis via MTS assay after 48 h (d); the results are expressed as the mean ± SD. ANOVA *** p < 0.001; n = 3

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