Fig. 10From: The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cellsRelative protein expression of phosphorylated and total ERK1/2 (a) and phosphorylated SAPK (b) in H295R cells. (−) treated with DMSO or (+) 10 μM Nilotinib for 15 and 60 min. The results are expressed as the mean ± SD. Paired t test, n = 3. Relative protein expression of phosphorylated and total ERK1/2 in H295R cells (−) treated with DMSO or (+) 10 μM U0126 for 60 min or/and (+) Nilotinib for 60 min (c). Cell viability analysis via MTS assay after 48 h (d); the results are expressed as the mean ± SD. ANOVA *** p < 0.001; n = 3Back to article page