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Fig. 6 | Cancer Cell International

Fig. 6

From: Arachidonic acid-induced Ca2+ entry and migration in a neuroendocrine cancer cell line

Fig. 6

Effect of SOCE and AA-induced Ca2+ entry on cell migration. a Bar chart showing average percentage of cells that migrated in response to activation or pharmacological inhibition of SOCE and AA-induced Ca2+ entry (treatments indicated). b Bar chart showing average percentage of cell migration in response to pharmacological inhibition of AA metabolic pathways. Significance of p < 0.001 is indicated by ***. Effect of knock down of Orai1 and Orai3 on cell migration. c Representative fluorescent image showing migrated cells: Top left: migration of cells transfected with scrambled shRNA in response to SFM. Top right: migration of scrambled shRNA transfected cells in response to 6 μM AA. Bottom left: migration of Orai1 shRNA transfected cells in response to 6 μM AA. Bottom right: migration of cells transfected with Orai3 shRNA in response to 6 μM AA. Scale bars indicate 50 μm. d Bar chart showing average migration of cells in response to treatments indicated in (c). Significance of p < 0.001 is indicated by ***

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