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Fig. 6 | Cancer Cell International

Fig. 6

From: Transcription factor E2F3a regulates CASP8AP2 transcription and enhances sensitivity to chemotherapeutic drugs in acute lymphoblastic leukemia

Fig. 6

Knockdown of CASP8AP2 reversed the effect of E2F3a on chemotherapeutic sensitivity of 697. a CASP8AP2 knockdown with shCASP8AP2 in 697 over-expressing E2F3a. b IC50 of VCR was increased in 697 over-expressing E2F3a after CASP8AP2 knockdown (P = 0.0105). c IC50 of DNR tended to increase in 697 over-expressing E2F3a after CASP8AP2 knockdown (P = 0.0562). Independent-samples T test was used to compare the regression coefficients of the two curves. The standard errors of the means are shown (n = 3 experiments for each drug concentration)

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