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Fig. 4 | Cancer Cell International

Fig. 4

From: Characterization of MCF-12A cell phenotype, response to estrogens, and growth in 3D

Fig. 4

3D growth of MCF-12A cells in rat-tail collagen after 14 days. Confocal projections of select structures (top row) and E-cadherin stained cross sections of corresponding structures (bottom row). MCF-12A cells form hollow (a) and solid acini (b) as well as solid bifurcating ducts (c) and lumenized branching ducts (d). Spherical clusters of concentric cells are often seen within elongated ductal structures (black arrow). Scale bar = 100 µm

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