Table 3 List of DNA repair enzymes de-regulated in HCC
From: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
S .No. | DNA repair enzyme | Therapy given | Repair mechanism involved | Reference |
|---|---|---|---|---|
1 | ERCC-1 | Platinum based anti-cancer agents | Nucleotide excision repair (NER) | [105] |
2 | Flap endonucleases (FENs) | Cisplatin | Nucleotide excision repair (NER) and Base excision repair (BER) | [106] |
3 | Chk2 | Paclitaxel | DNA damage checkpoint | [107] |
4 | ATM signaling | Sorafenib | DNA damage checkpoint | [108] |
5 | Apurinic/apyrimidinic endonuclease (APE1) | Irradiation | Base excision repair (BER) | [109] |