Table 5 List of miRNAs de-regulated in HCC
From: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
S. No. | MiRNAs deregulated in HCC | Mechanism | Expression Level | Reference |
|---|---|---|---|---|
1 | miR-21 | Potential biomarker for early stage HCC diagnosis | Up-regulated | [115] |
2 | miR-338-3p | Suppresses HCC cell invasion by inhibiting metalloproteinase (MMP-9) | Down-regulated | [116] |
3 | miR-122 | Inhibits cycle cyclins & reduces MDR expression | Down-regulated | [117] |
4 | miR-181& let-7 | IL-6 and twist-regulated miRNA expression | Up-regulated | [118] |
5 | miR-193a-3p | Affects DNA methylation state | Up-regulated | [119] |
6 | miR-199a/b-3p | Targets mTOR and c-met | Down-regulated | [120] |
7 | miR-210 | Targets apoptosis-inducing factor, mitochondrion-associated, 3 (AIFM3) in hypoxic HCC | Down-regulated | [121] |
8 | miR-494 | Reduces the expression of PTEN but increases PI3Â K and p-Akt expression | Up-regulated | [122] |
9 | miR-1180 | Activates NF-κB pathway by downregulating its negative regulators | Up-regulated | [123] |
10 | miR-122 | Up-regulates IGF-1R that contribute to activation of RAS/RAF/ERK signaling which is associated with drug resistance | Down-regulated | [124] |