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Table 7 Drugs targeting TME in clinical trials for HCC treatment

From: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight

S. No.

Drug

Molecular targets

Phases of clinical trial

Year and references

1

Sibrotuzumab

FAPs

I

2003 [134]

2

PI-88

HPR

II

2009 [135]

3

Selumetinib

MEK

II

2011 [136]

4

Brivanib

VEGFR, PDGFR

III

2013 [137]

5

Lilifanib

VEGFR

III

2013 [138]

6

Axitinib

VEGFR

II

2015 [139]

7

Galuniserib

TGF-β

I

2015 [140]

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Cancer Cell International

ISSN: 1475-2867

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