Table 9 Application of CAR-T cells for HCC
From: Resistance a major hindrance to chemotherapy in hepatocellular carcinoma: an insight
S. No. | Antigen | Gene transfer vehicle | Phases of clinical trial | Year (Clinicaltrials.gov identifier or reference) |
|---|---|---|---|---|
1 | Epidermal growth factor receptor | Lentivirus | I/II | 2013 [148] |
2 | Mucin-1 | – | I/II | 2015 (NCT02587689) |
3 | CD133 | Retrovirus | I | 2015 (NCT02541370) |
4 | Carcinoembryonic antigen | Retrovirus | Preclinical | 2016 [149] |
5 | Epithelial cell adhesion molecule | – | I/II | 2016 (NCT02729493) |
6 | Glypican-3 | – | I/II | 2016 (NCT02723942) |