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Fig. 2 | Cancer Cell International

Fig. 2

From: Tumor-suppressor role of miR-139-5p in endometrial cancer

Fig. 2

HOXA10 is a candidate target of miR-139-5p. a Computational analysis identified that HOXA10 may be a potential target of miR-139-5p, and the predicted binding sequences of HOXA10 3′-UTR and miR-139-5p were marked. b Dual luciferase assay performed in HEK-293T cells confirms that HOXA10 is the target gene of the miR-139-5p. A significant decrease in relative luciferase activity was noted when pGL3-HOXA10-3′-UTR was co-transfected with the miR-139-5p mimic but not with the miRNA mimic control. c, d I HOXA10 expression levels, by western blot analysis, in ECC1 and Ishikawa cells upon miR-139-5p or negative control reintroduction. c, d II Histograms represent densitometric analysis. All experiments were performed in triplicate. **P < 0.01

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