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Table 1 Inhibitory concentration 50 (IC50)

From: Autophagy inhibition improves the cytotoxic effects of receptor tyrosine kinase inhibitors

Drug IC50 at 24 h (mean ± SD) μM
Afatinib 7.7 ± 0.6
Sorafenib 12.4 ± 3.4
TP-0903 0.130 ± 0.009
  1. The concentration that inhibits cell viability for 50% was determine for each RTKi (Afatinib, Sorafenib and TP-0903). The mean values and standard deviations are indicated for 24 h treatment period