Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma

Table 3 Meta-analysis of CYP2E1 rs3813867 G/C polymorphism and SCC risk

Comparisons	Group	Number (study)	OR	95% CI	P (association)
Allele model (allele C vs. allele G)	All	10	0.72	0.63–0.83	< 0.001
	Asian	4	0.67	0.57–0.78	< 0.001
	HNSCC	5	0.97	0.73–1.30	0.863
	ESCC	4	0.68	0.57–0.82	< 0.001
	PB	5	0.65	0.53–0.79	< 0.001
	HB	5	0.80	0.66–0.97	0.021
	Y	10	0.72	0.63–0.83	< 0.001
Carrier model (carrier C vs. carrier G)	All	10	0.79	0.68–0.92	0.002
	Asian	4	0.75	0.63–0.90	0.001
	HNSCC	5	0.94	0.70–1.27	0.698
	ESCC	4	0.77	0.63–0.93	0.008
	PB	5	0.72	0.58–0.89	0.003
	HB	5	0.85	0.70–1.05	0.133
	Y	10	0.79	0.68–0.92	0.002
Homozygote model (CC vs. GG)	All	6	0.38	0.24–0.61	< 0.001
	Asian	4	0.30	0.18–0.50	< 0.001
	HNSCC	2	2.34	0.58–9.34	0.230
	ESCC	3	0.30	0.17–0.53	< 0.001
	PB	3	0.43	0.24–0.75	0.003
	HB	3	0.30	0.12–0.74	0.009
	Y	6	0.38	0.24–0.61	< 0.001
Heterozygote model (GC vs. GG)	All	10	0.82	0.63–107	0.150
	Asian	4	0.75	0.56–0.99	0.045
	HNSCC	5	1.15	0.62–2.16	0.657
	ESCC	4	0.76	0.54–1.07	0.116
	PB	5	0.66	0.51–0.84	0.001
	HB	5	1.09	0.67–1.76	0.730
	Y	10	0.82	0.63–107	0.150
Dominant model (GC + CC vs. GG)	All	11	0.76	0.60–0.97	0.024
	Asian	4	0.68	0.54–0.86	0.002
	HNSCC	6	1.01	0.62–1.65	0.961
	ESCC	4	0.70	0.53–0.92	0.011
	PB	6	0.62	0.50–0.77	< 0.001
	HB	5	1.03	0.65–1.62	0.916
	Y	11	0.76	0.60–0.97	0.024
Recessive model (CC vs. GG + GC)	All	6	0.43	0.27–0.68	< 0.001
	Asian	4	0.34	0.20–0.57	< 0.001
	HNSCC	2	2.39	0.60–9.53	0.218
	ESCC	3	0.35	0.20–0.60	< 0.001
	PB	3	0.49	0.28–0.86	0.013
	HB	3	0.31	0.13–0.77	0.011
	Y	6	0.43	0.27–0.68	< 0.001

OR odds ratio, CI confidence interval, HNSCC head and neck squamous cell carcinoma, ESCC esophageal squamous cell carcinoma, PB population-based control, HB hospital-based control, Y P value of hardy–weinberg equilibrium > 0.05

ISSN: 1475-2867