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Table 4 Meta-analysis of CYP2E1 rs2031920/rs3813867 haplotype and SCC risk

From: Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma

Comparisons

Group

Number (study)

OR

95% CI

P (association)

Allele c2 vs. allele c1

All

5

0.65

0.49–0.86

0.003

 

HNSCC

3

1.01

0.57–1.78

0.977

 

PB

3

0.57

0.42–0.79

0.001

 

Y

4

0.98

0.65–1.46

0.913

Carrier c2 vs. carrier c1

All

5

0.73

0.53–1.00

0.047

 

HNSCC

3

0.98

0.55–1.75

0.945

 

PB

3

0.65

0.45–0.93

0.019

 

Y

4

0.98

0.64–1.50

0.938

c2c2 vs. c1c1

All

3

0.41

0.20–0.86

0.018

c1c2 vs. c1c1

All

5

0.75

0.43–1.30

0.309

 

HNSCC

3

0.96

0.53–1.71

0.877

 

PB

3

0.63

0.29–1.35

0.231

 

Y

4

1.00

0.64–1.56

0.990

c1c2 + c2c2 vs. c1c1

All

7

0.72

0.55–0.94

0.016

 

HNSCC

4

0.97

0.59–1.57

0.892

 

PB

4

0.64

0.47–0.87

0.005

 

Y

6

0.97

0.70–1.35

0.871

c2c2 vs. c1c1 + c1c2

All

3

0.55

0.26–1.13

0.103

  1. OR odds ratio, CI confidence interval, HNSCC head and neck squamous cell carcinoma, PB population-based control, Y P value of hardy–weinberg equilibrium > 0.05