Fig. 3
From: Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs
PI3K as a key component of TMZ resistance in GBM cells. a PI3K inhibition (20 µM LY294002) sensitizes all GBM cells to TMZ (1000 µM) (n = 3). b MTT concentration response curve showing concentration dependency of sensitization by LY294002 in U251 cells (upper graph). Respective TMZ IC50 values at increasing LY294002 concentrations are displayed in the table below the graph (n ≥ 3). c Both, LY294002 (5 µM) and Wortmannin (30 nM), sensitize GBM cell lines to cisplatin. Presented IC50 values were derived from MTT assays (n = 3). *P < 0.05, ***P < 0.001