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Fig. 6 | Cancer Cell International

Fig. 6

From: Inhibition of the PI3K but not the MEK/ERK pathway sensitizes human glioma cells to alkylating drugs

Fig. 6

PI3K but not MEK inhibition sensitizes human primary GBM cells to TMZ. a PI3K inhibition (20 µM LY294002) leads to a left shift of the TMZ concentration response curve (n = 3). b Neither, U0126 (5 and 20 µM; n ≥ 3) c nor PD98059 (5 and 20 µM; n ≥ 3) sensitize primary cells to TMZ. d Derived mean IC50 values for TMZ of respective primary GBM cells treated with LY294002 and MEK inhibitors (20 µM each; n ≥ 3). *P < 0.05

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