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Fig. 6 | Cancer Cell International

Fig. 6

From: LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

Fig. 6

Chemical inhibition of LSD1 depletes AR activity in an AR-V7 expressing 22Rv1 prostate cancer cells. 22Rv1 cells, expressing both endogenous AR-WT and V7 splice variants, were incubated in CSS-media for 24 h prior to adding dihydrotestosterone (DHT, 1 nM) and LSD1-C76 (250 μM) for 18 h as indicated (or DMSO solvent control). a Western blot analysis of AR and LSD1 expression. b PSA mRNA expression determined by qPCR in three independent experiments. P values were derived using an unpaired t test with Welch’s correction. ****P < 0.05

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