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Table 1 IC50 and LD50 values for LSD1 inhibitor compounds for in vitro LSD1 inhibition assays and LNCaP prostate cancer cell proliferation assays respectively

From: LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models

Compound LSD1 inhibition Cell proliferation
IC50 mean (nM) SD (nM) LD50 mean (μM) SD (μM)
Tranylcypromine (1) 57,980.0 5922.9 2235.0 173.6
2 4389.0 157.9 136.3 1.7
3 1520.5 890.3 605.9 90.4
4 259.3 22.8 224.9 27.9
5 269.4 35.7 712.4 48.5
6 221.6 26.7 183.9 19.6
LSD1-C76 527.0 9.0 85.1 9.5
  1. Data represent mean values ± standard deviation (SD), as indicated, for a minimum of three experiments in each case