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Fig. 7 | Cancer Cell International

Fig. 7

From: Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Fig. 7

DYRK gene NB tumor mRNA expression and prognostic significance. The mRNA expression of the DYRK gene family was analyzed in SEQC-498, the largest genome-wide RNA sequencing dataset on human NB tumors in the public domain. a Bar plot of DYRK gene tumor mRNA expression in the SEQC-498 patient cohort. The Y-axis represents expression in RPM (reads per million), vertical bars represent mean expression ± standard deviation. All five DYRK genes show significant expression, with DYRK1A and DYRK2 as the most highly expressed mRNAs. bf Kaplan–Meier graphs representing the overall survival prognosis of NB patients in the SEQC-498 cohort based on grouping of the patients according to median DYRK gene tumor mRNA expression. ce High-level tumor mRNA expression of DYRK1B, DYRK2, and DYRK3 is significantly predictive of poor patient outcome. Significant correlations are also found when patients are grouped according to, e.g. average DYRK mRNA tumor expression, or when event-free survival is predicted (results not shown), suggesting that DYRK mRNA expression is a robust predictor for NB patient outcome

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