Fig. 8

DYRK gene NB tumor expression correlated to MYCN gene amplification. The mRNA expression of the DYRK gene family was analyzed in SEQC-498 and correlated to MYCN amplification by separating the tumors into samples with normal MYCN gene copy number (n = 401) and with MYCN amplification (n = 92) and comparing the groups using the non-parametric Kruskal–Wallis test. The Y-axis represents DYRK gene mRNA expression (rank-based). The results show that DYRK1A mRNA expression is highest in tumors without MYCN amplification, but that both DYRK2 and DYRK3 are most highly expressed in tumors with MYCN amplification. DYRK1B and DYRK4 expression are not correlated to MYCN gene copy number