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Fig. 9 | Cancer Cell International

Fig. 9

From: Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma

Fig. 9

Cytotoxic effects of DYRK inhibitors after 24 h of treatment in NB cells using the SRB assay. a The DYRK2 inhibitor LDN-192960 strongly inhibited cell proliferation of four NB cell lines SKNBE, KELLY, SKNAS, and SKNFI in a dose-dependent manner. b In contrast, the DYRK1A/B inhibitor INDY only minimally inhibited cell proliferation under identical conditions. The time zero (T = 0) values for each cell line prior to treatment were subtracted from the 24 h readings. Data represent the average of three independent experiments, each performed in duplicate ± S.D. (n = 6)

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