Fig. 7From: ETS1 is associated with cisplatin resistance through IKKα/NF-κB pathway in cell line MDA-MB-231Proposed model for ETS1 activation of IKKα/NF-κB pathway inducing DDP resistance. Up-regulation of ETS1 activates IKKα, though its promoter sites binding, then activation NF-κB pathway which is a non-classic pathway. Next, the activation of NF-κB occurs nuclear translocation and increases expression of ATP transports which could be causing DDP resistanceBack to article page