Fig. 2

Knockdown of PVT1 inhibited HCC cell proliferation and promoted cell apoptosis. a PVT1 was highly expressed in four HCC cell lines (HepG2, Huh7, SK-HEP-1 and BEL-7404) compared with normal cell line (HL-7702). **P < 0.01, *P < 0.05, compared with HL-7702 cell line. b PVT1 expression in HepG2 and Huh7 cells transfected with si-PVT1 was lower than that in cells transfected with si-NC. *P < 0.05, compared with si-NC group. c Cell vitality of HepG2 and Huh7 cells transfected with si-PVT1 was lower than that in cell s transfected with si-NC detected by CCK-8 assay. *P < 0.01, **P < 0.05, compared with si-NC group. d Colony formation assay indicated that the number of colony cells in si-PVT1 group was lower than that in si-NC group. *P < 0.05, compared with si-NC group. e Flow cytometry showed that apoptosis rate in si-PVT1 group was higher than that in si-NC group. *P < 0.05, compared with si-NC group