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Fig. 2 | Cancer Cell International

Fig. 2

From: The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer

Fig. 2

Expression patterns of SEMA5A and LYVE-1 in metastatic and nonmetastatic cervical cancers. A SEMA5A protein was present in cervical cancer cells that metastasized to the regional lymph nodes. Immunohistochemical staining of LYVE-1 in B metastatic and C nonmetastatic cervical cancers. Numerous peritumoral LYVE-1-stained lymphatics were observed in metastatic cervical cancer specimens, whereas few peritumoral LYVE-1-stained lymphatics were observed in nonmetastatic cervical cancer specimens. D The typical lymphovascular invasions with tumor cell clusters in a LYVE-1-stained lymphatic vessels. A ×200 magnification B–D ×100 magnification. LYVE lymphatic vessel endothelial hyaluronan receptor-1, SEMA5A semaphorin 5A

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