The association of semaphorin 5A with lymph node metastasis and adverse prognosis in cervical cancer

Table 3 Relationship between clinicopathological characteristics and SEMA5A expression in cervical cancer patients (n = 232)

Clinicopathological characteristics	SEMA5A expression		P value
Clinicopathological characteristics	Low (n = 109)	High (n = 123)	P value
Age (years)
≤ 45	47	60	0.388
> 45	62	63	0.388
FIGO stage
Ia	9	3	0.019^a
Ib	44	35
IIa	32	55
IIb	24	30
Tumor grade
High	28	19	0.090
Intermediate	49	55
Low	32	49
Histological type
Squamous carcinoma	76	80	0.262
Adenocarcinoma	29	32
Adenosquamous carcinoma	4	11
Lymphatic permeation
No	96	94	0.021^a
Yes	13	29	0.021^a
VEGF-C expression
High	19	101	< 0.001^a
Low	90	22	< 0.001^a
Lymphatic microvessel density
High	23	92	< 0.001^a
Low	86	31	< 0.001^a
Lymph node metastasis
No	68	43	< 0.001^a
Yes	41	80	< 0.001^a

FIGO Federation of Gynecology and Obstetrics, SEMA5A semaphorin 5A, VEGF-C vascular endothelial growth factor-C
^aChi square test P < 0.05

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