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Table 2 Genes with more than one promoter CpG site hypermethylated in TMX2-28 compared to MCF-7 and with decreased methylation after 5-Aza-dC treatment

From: TROP2 methylation and expression in tamoxifen-resistant breast cancer

  1. Gray shading highlights two genes with decreased expression in TMX2-28 that were re-expressed after treatment with 5-Aza-dC
  2. Blue shading highlights an additional four genes with decreased expression in TMX2-28
  3. nt not tested
  4. aNumber of CpGs in the promoter region that are hypermethylated in TMX2-28
  5. bMean methylation in TMX2-28 compared to MCF7 (fold higher in TMX2-28)
  6. cMean methylation in TMX2-28 compared to TMX2-28 after 72 h treatment with 5-Aza-dC treatment (fold higher in TMX2-28)
  7. dComaprison of mRNA levels in TMX2-28 to MCF7 (direction)
  8. eComparison of mRNA levels in TMX2-28 to TMX2-28 after 72 h treatment with 5-Aza-dC (direction)
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Cancer Cell International

ISSN: 1475-2867

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