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Fig. 4 | Cancer Cell International

Fig. 4

From: MiR-98 modulates macrophage polarization and suppresses the effects of tumor-associated macrophages on promoting invasion and epithelial–mesenchymal transition of hepatocellular carcinoma

Fig. 4

MiR-98 regulates expression of inflammatory cytokines in HCC-conditioned TAMs. a The expression levels of miR-98 in M2 and TAMs were significantly decreased compared with the M0 group. Next, TAMs were transfected with miR-98 mimic, mimic NC, miR-98 inhibitor or inhibitor NC. Quantitative real-time PCR showed that miR-98 level b in TAMs was significantly up-regulated by miR-98 mimic, and c was significantly down-regulated by miR-98 inhibitor. d ELISA assay showed that the levels of TNF-α and IL-1β were significantly increased whereas the levels of TGF-β and IL-10 were significantly decreased in HCC-conditioned TAMs that had been transfected with miR-98 mimic compared with the control group. e ELISA assay showed that the levels of TNF-α and IL-1β were significantly decreased whereas the levels of TGF-β and IL-10 were significantly increased in HCC-conditioned TAMs that had been transfected with miR-98 inhibitor compared with the control. **P < 0.01 and ***P < 0.001 vs. the corresponding control group

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Cancer Cell International

ISSN: 1475-2867

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