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Table 3 Association between the two SNPs and risk of lung adenocarcinoma and squamous cell lung cancer

From: Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer

Genotype Controls (%) (593) Lung adenocarcinoma Squamous cell carcinoma
Cases (%) (233) ORa (95 %CI) P value Cases (%) (89) ORa (95% CI) P value
Rs4848320
 CC (ref) 402 (67.8) 159 (68.2) 1.00 (ref)   58 (65.2) 1.00 (ref)  
 CT 175 (29.5) 68 (29.2) 0.957 (0.679–1.350) 0.804 28 (31.5) 1.127 (0.690–1.840) 0.634
 TT 16 (2.7) 6 (2.6) 0.910 (0.343–2.413) 0.849 3 (3.4) 1.230 (0.339–4.466) 0.753
 CT + TT vs CC    0.953 (0.683–1.331) 0.779   1.135 (0.706–1.826) 0.600
 TT vs CT + CC    0.922 (0.350–2.431) 0.870   1.184 (0.329–4.259) 0.796
Rs1110839
 TT (ref) 250 (42.2) 102 (43.8) 1.00 (ref)   30 (33.7) 1.00 (ref)  
 TG 274 (46.2) 107 (45.9) 0.960 (0.691–1.334) 0.808 46 (51.7) 1.336 (0.813–2.195) 0.253
 GG 69 (11.6) 24 (10.3) 0.805 (0.474–1.368) 0.423 13 (14.6) 1.605 (0.787–3.273) 0.193
 TG + GG vs TT    0.928 (0.678–1.270) 0.639   1.388 (0.864–2.229) 0.175
 GG vs TG + TT    0.822 (0.498–1.359) 0.445   1.362 (0.712–2.608) 0.350
  1. SNP single nucleotide polymorphism, OR odds ratio, CI confident interval
  2. ORa was adjusted by age, gender and smoking