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Table 3 Association between the two SNPs and risk of lung adenocarcinoma and squamous cell lung cancer

From: Polymorphism in lncRNA AC016683.6 and its interaction with smoking exposure on the susceptibility of lung cancer

Genotype

Controls (%) (593)

Lung adenocarcinoma

Squamous cell carcinoma

Cases (%) (233)

ORa (95 %CI)

P value

Cases (%) (89)

ORa (95% CI)

P value

Rs4848320

 CC (ref)

402 (67.8)

159 (68.2)

1.00 (ref)

 

58 (65.2)

1.00 (ref)

 

 CT

175 (29.5)

68 (29.2)

0.957 (0.679–1.350)

0.804

28 (31.5)

1.127 (0.690–1.840)

0.634

 TT

16 (2.7)

6 (2.6)

0.910 (0.343–2.413)

0.849

3 (3.4)

1.230 (0.339–4.466)

0.753

 CT + TT vs CC

  

0.953 (0.683–1.331)

0.779

 

1.135 (0.706–1.826)

0.600

 TT vs CT + CC

  

0.922 (0.350–2.431)

0.870

 

1.184 (0.329–4.259)

0.796

Rs1110839

 TT (ref)

250 (42.2)

102 (43.8)

1.00 (ref)

 

30 (33.7)

1.00 (ref)

 

 TG

274 (46.2)

107 (45.9)

0.960 (0.691–1.334)

0.808

46 (51.7)

1.336 (0.813–2.195)

0.253

 GG

69 (11.6)

24 (10.3)

0.805 (0.474–1.368)

0.423

13 (14.6)

1.605 (0.787–3.273)

0.193

 TG + GG vs TT

  

0.928 (0.678–1.270)

0.639

 

1.388 (0.864–2.229)

0.175

 GG vs TG + TT

  

0.822 (0.498–1.359)

0.445

 

1.362 (0.712–2.608)

0.350

  1. SNP single nucleotide polymorphism, OR odds ratio, CI confident interval
  2. ORa was adjusted by age, gender and smoking