Table 8 Crossover analysis of interaction between rs4848320, rs1110839 risk genotypes and smoking exposure
SNPs | Genotype | Smoking exposure | Controls (%) | Cases (%) | ORa (95% CI) | P value |
|---|---|---|---|---|---|---|
Rs4848320 | CC | Never | 314 (53.0) | 233 (53.7) | 1 (ref) | Â |
CT + TT | Never | 161 (27.2) | 105 (24.2) | 0.875 (0.648–1.182) | 0.384 | |
CC | Ever | 88 (14.8) | 58 (13.4) | 1.129 (0.738–1.728) | 0.576 | |
CT + TT | Ever | 30 (5.1) | 85 (31.8) | 2.218 (1.272–3.869) | 0.005 | |
Rs1110839 | TT | Never | 200 (33.7) | 144 (33.2) | 1 (ref) | Â |
TG + GG | Never | 275 (46.4) | 194 (44.7) | 0.968 (0.729–1.286) | 0.822 | |
TT | Ever | 50 (8.4) | 30 (6.9) | 1.043 (0.611–1.782) | 0.877 | |
TG + GG | Ever | 68 (11.5) | 66 (15.2) | 1.755 (1.108–2.781) | 0.017 |