Table 1 NLC delivery for miRNA in tumor gene therapy

Cationic NLC

miR-34a

B16F10 melanoma lung metastasis [26]

N/A

miR-107

Head and neck squamous carcinoma [27]

N/A

miR-7

Lung cancer [28, 29]

N/A

miR-34a/miR-143/miR-145

Pancreatic carcinoma [30]

N/A

miR-101

Hepatocarcinoma [31]

N/A

miR-375

Hepatocellular carcinoma [34]

Liver tissue, kidney tissue

Neutral NLC

miR-124

Lung cancer [4]

Lung tissue

let-7

Lung cancer [4]

N/A

miR-34a

Lung cancer [39]

N/A

miR-34a

Diffuse large B cell lymphoma [40]

N/A

miR-495

Lung cancer [41]

N/A

Targeting-modified NLC

miRNA-125a-5p

Breast cancer [43]

N/A

miR-34a

B16F10 melanoma lung metastasis [26]

N/A

anti-miR-221

Hepatocarcinoma [44]

N/A

let-7a

NSCLC [45]

N/A

anti-miR-21

Glioblastoma [46]

Brain tissue