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Fig. 5 | Cancer Cell International

Fig. 5

From: B7-H4 overexpression contributes to poor prognosis and drug-resistance in triple-negative breast cancer

Fig. 5

a B7-H4 silencing or treatment of mAb MIH43 sensitized breast cancer cells to DOX-induced apoptosis. The percentage of apoptotic cells was investigated by measuring DNA fragmentation by apoptosis-specific ELISA detection kit. b B7-H4 silencing or treatment of mAb MIH43 increased apoptosis via promoting cleaved-PARP, cleaved-Caspase-3, cleaved-Caspase-7 and cleaved-Caspase-9 fragmentations. c Knockdown of B7-H4 or treatment of mAb MIH43 enhanced the level of PTEN and abolished the phosphorylation level of PI3K and AKT, whereas overexpression of B7-H4 could counteract these effects

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Cancer Cell International

ISSN: 1475-2867

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