Table 1 Correlation between B7-H4 expression and clinicopathological parameters in TNBC
Parameters | n | B7-H4 expression | p | B7-H4 intensity | p | |||
|---|---|---|---|---|---|---|---|---|
Low | High | Weak | Moderate | Strong | ||||
Age | ||||||||
 ≤ 50 | 30 | 5 | 25 | 0.612 | 4 | 14 | 12 | 0.664 |
 > 50 | 29 | 5 | 24 | 3 | 11 | 15 | ||
Menopausal | ||||||||
 Premenopausal | 30 | 6 | 24 | 0.425 | 5 | 13 | 12 | 0.440 |
 Postmenopausal | 29 | 5 | 24 | 2 | 12 | 15 | ||
Tumor histology | ||||||||
 IDC | 45 | 10 | 35 | 0.051 | 7 | 21 | 17 | 0.059 |
 Non-IDC | 14 | 1 | 13 | 0 | 4 | 10 | ||
Tumor size | ||||||||
 ≤ 2 | 4 | 3 | 1 | 0.055 | 1 | 2 | 1 | 0.113 |
 2–5 | 42 | 7 | 35 | 6 | 20 | 16 | ||
 > 5 | 13 | 0 | 13 | 0 | 3 | 10 | ||
Tumor grade | ||||||||
 I–II | 26 | 9 | 17 | 0.002 | 7 | 12 | 7 | 0.004 |
 III | 33 | 1 | 32 | 0 | 13 | 20 | ||
TNM stage | ||||||||
 I | 3 | 3 | 0 | 0.006 | 1 | 2 | 0 | 0.003 |
 II | 41 | 7 | 34 | 6 | 22 | 13 | ||
 III | 15 | 0 | 15 | 0 | 1 | 14 | ||
Metastasis | ||||||||
 Yes | 21 | 9 | 12 | 0.001 | 7 | 10 | 4 | 0.001 |
 No | 38 | 2 | 36 | 0 | 15 | 23 | ||
Ki-67 | ||||||||
 + | 8 | 4 | 4 | 0.053 | 3 | 3 | 2 | 0.062 |
 ++ | 29 | 6 | 23 | 4 | 13 | 12 | ||
 +++ | 22 | 2 | 20 | 2 | 7 | 13 | ||
AR | ||||||||
 − | 38 | 3 | 35 | 0.007 | 2 | 11 | 25 | 0.003 |
 + | 21 | 9 | 12 | 6 | 10 | 5 | ||
Recurrence | ||||||||
 Yes | 25 | 9 | 16 | 0.003 | 7 | 10 | 8 | 0.002 |
 No | 34 | 4 | 30 | 2 | 13 | 19 | ||