Clinicopathological and prognostic significance of long noncoding RNA MALAT1 in human cancers: a review and meta-analysis

Table 3 Association between MALAT1 expression and RFS/DFS/DSS/PFS

Survival outcome	Survival analysis	Studies (n)	Patients (n)	HR (95% CI)	P	Heterogeneity (I², P value)
RFS	Univariate	5	397	1.355 (0.751–2.445)	0.313	70.6%, 0.009
RFS	Multivariate	3	263	2.491 (1.505–4.123)	0.000	0.0%, 0.435
DFS	Univariate	1	77	1.820 (1.018–3.255)	0.044	–
DFS	Multivariate	3	329	2.036 (1.240–3.342)	0.005	32.7%, 0.226
DSS	Univariate	3	2037	1.791 (1.304–2.459)	0.000	4.5%, 0.351
DSS	Multivariate	3	2037	2.098 (1.372–3.211)	0.001	0.0%, 0.578
PFS	Univariate	1	100	3.03 (1.578–5.820)	0.001	–
PFS	Multivariate	2	175	1.842 (1.138–2.983)	0.013	0.0%, 0.940

If I² > 50%, the results were calculated by random model
DFS disease-free survival, RFS recurrence-free survival, DSS disease-specific survival, PFS progression-free survival, HR hazard ratio, CI confidence interval

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