Cancer type | Expression effect | Transition of cell phenotype of MALAT1 silencing | Molecular mechanisms | References |
---|---|---|---|---|
Breast cancer | Up-regulated | G0/G1 phase cell cycle arrest; ↓ proliferation/migration/invasion | MALAT1 influenced cells progression by miR-129-5p; MALAT1 functions as a ceRNA of cdc42 in inducing EMT by binding miR-1 competitively | |
Gallbladder cancer | Up-regulated | ↓ Proliferation and metastasis | MALAT1 activates the ERK/MAPK pathway | [70] |
Colorectal cancer | Up-regulated | ↓ Proliferation/migration/invasion | Knockdown of AKAP-9 blocks MALAT1-mediated proliferation, migration and invasion; MALAT1 might bind to SFPQ, therefore releasing PTBP2 from the SFPQ/PTBP2 complex; SFPQ regulated the effect of MALAT1 on cell proliferation and migration | |
Osteosarcoma | Up-regulated | ↓ Invasion/proliferation/metastasis | MALAT1 knockdown inhabits PI3K/Akt pathways | [62] |
Lung cancer | Up-regulated | ↓ Migration/growth/invasion | MALAT1 regulates by TDP-43; MALAT1 silencing reduces the expression of CXCL5; the promoter methylation regulates MALAT1 expression; MALAT1 up-regulated the expression of miR-204 target gene SLUG through competitively ‘sponging’ miR-204 | |
Pancreatic cancer | Up-regulated | G2/M cell cycle arrest; ↑ apoptosis; ↓ proliferation/metastasis/migration/invasion | MALAT1 promotes proliferation and metastasis by the stimulation of autophagy and inducing EMT | |
Cervical cancer | Up-regulated | ↓ Invasion/metastasis; ↑ apoptosis | MALAT1 regulates EMT by up-regulating transcriptional factor Snail | |
Gastric cancer | Up-regulated | ↓ Proliferation/migration/invasion/metastasis | MALAT1 regulates via increasing EGFL7 expression; MALAT1 regulates VE-cadherin/β-catenin complex, ERK/MMP and FAX/paxillin singling pathways involved in VM formation and angiogenesis; MALAT1 regulates miR-1297 to modulate HMGB2 | |
Esophageal squamous cell carcinoma | Up-regulated | ↓ Proliferation/migration/invasion/metastasis; ↑ apoptosis; G2/M phase cell cycle arrest | MALAT1 regulates the expression of β-catenin and Lin28 via Ezh2; Silencing of MALAT1 caused by miR-101 and miR-217; Knockdown of MALAT1 induces cell cycle arrest by activating the ATM-CHK2 pathway | |
Hepatocellular carcinoma | Up-regulated | ↓ Proliferation/invasion | MALAT1 regulates ZEB1 expression by sponging miR-143-3p | [14] |
Renal cell carcinoma | Up-regulated | ↓ Proliferation/invasion; ↑ apoptosis | Knockdown of MALAT1 significantly increases miR-205 expression in renal cancer cells; MALAT1 silencing elevated E-cadherin expression, whereas b-catenin expression reduced through Ezh2 to block EMT | [33] |
Mantle cell lymphoma | Up-regulated | ↓ Proliferation; ↑ apoptosis; S/G1 phase cell cycle arrest | MALAT1 represses the expression of PRC2-dependent target genes by ineracting with EZH2 | [48] |
Prostate cancer | Up-regulated | ↓ Growth/invasion/migration; G0/G1 phase cell cycle arrest | MALAT1 increases oncogenic activities of EZH2 | |
Pancreatic ductal adenocarcinoma | Up-regulated | ↓ Proliferation/migration/invasion/growth and cell cycle progression; ↑ apoptosis | MALAT1 acts as a ceRNA to regulate KRAS expression by sponging miR-217 | [72] |
Bladder cancer | Up-regulated | ↓ Migration and metastasis | MALAT1 regulates TGF-b-induced EMT; MALAT1 promotes EMT by activating the Wnt/β-catenin signaling pathway | |
Epithelial ovarian cancer | Up-regulated | ↓ Proliferation/invasion/metastasis; ↑ apoptosis | MALAT1 induces EMT via PI3K/AKT pathway | [71] |
Glioma | Down-regulated | ↑ Proliferation/viability/progression | MALAT1 suppresses miR-155 expression and activates FBXW7 function | [52] |