Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis

Table 2 Meta-analysis of the association between elevated NLR and clinicopathological parameters

Association	No. of studies	No. of patients	Pooled HR (95% CI)	Heterogeneity
Association	No. of studies	No. of patients	Pooled HR (95% CI)	I² (%)	p-value
Ann Arbor stage	8	1525	2.121 (1.367–3.293)	76.9	< 0.001
IPI	7	1170	1.869 (0.881–3.962)	88.8	< 0.001
B symptoms	7	1474	1.867 (1.034–3.372)	84.3	< 0.001
BM involvement	4	1004	1.550 (1.148–2.094)	8.0	0.353
ECOG-PS	8	1525	2.786 (2.067–3.755)	0	0.673
Extranodal sites	7	1422	1.314 (0.809–2.133)	76.2	< 0.001
LDH	8	1525	2.911 (1.550–5.467)	88.7	< 0.001

IPI international prognostic index, BM bone marrow, ECOG-PS Cooperative Oncology Group performance status, LDH lactate dehydrogenase

ISSN: 1475-2867