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Table 2 Meta-analysis of the association between elevated NLR and clinicopathological parameters

From: Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis

Association No. of studies No. of patients Pooled HR (95% CI) Heterogeneity
I2 (%) p-value
Ann Arbor stage 8 1525 2.121 (1.367–3.293) 76.9 < 0.001
IPI 7 1170 1.869 (0.881–3.962) 88.8 < 0.001
B symptoms 7 1474 1.867 (1.034–3.372) 84.3 < 0.001
BM involvement 4 1004 1.550 (1.148–2.094) 8.0 0.353
ECOG-PS 8 1525 2.786 (2.067–3.755) 0 0.673
Extranodal sites 7 1422 1.314 (0.809–2.133) 76.2 < 0.001
LDH 8 1525 2.911 (1.550–5.467) 88.7 < 0.001
  1. IPI international prognostic index, BM bone marrow, ECOG-PS Cooperative Oncology Group performance status, LDH lactate dehydrogenase