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Table 3 Subgroup analysis and Meta regression of pooled HRs for OS in DLBCL patients with high NLR

From: Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis

Subgroup analysis No. of studies No. of patients Pooled HR (95% CI) Meta regression (p-value) Heterogeneity
Fixed Random I2 (%) p-value
Region
 Western 3 840 1.563 [1.149–2.126] 2.246 [0.888–5.681]   82.2 0.004
 Eastern 8 1315 1.665 [1.317–2.105] 1.701 [1.050–2.756] 0.657 69.8 0.003
Sample size
 < 200 6 616 1.542 [1.077–2.209] 1.921 [0.894–4.127] 0.952 75.1 0.001
 ≥ 200 4 1539 1.659 [1.334–2.064] 1.841 [1.187–2.853]   72.6 0.012
Cut-off value
 < 3.0 5 823 2.539 [1.784–3.612] 2.908 [1.755–4.819] 0.060 36.8 0.176
 ≥ 3.0 5 1332 1.368 [1.098–1.705] 1.287 [0.795–2.084]   75.5 0.003
NOS score
 ≥ 7 5 1687 1.656 [1.345-2.038] 1.787[1.242-2.571]   63.5 0.027
 < 7 5 468 1.627 [1.350-1.960] 1.826[1.238-2.692] 0.949 80.1 0.000
  1. NOS Newcastle–Ottawa Quality Assessment Scale