Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis

Table 4 Subgroup analysis and Meta regression of pooled HRs for PFS in DLBCL patients with high NLR

Subgroup analysis	No. of studies	No. of patients	Pooled HR (95% CI)		Meta regression (p -value)	Heterogeneity
Subgroup analysis	No. of studies	No. of patients	Fixed	Random	Meta regression (p -value)	I² (%)	p-value
Region
Western	2	358	3.885 [2.185–6.907]	3.885 [2.185–6.907]	0.027	0	0.926
Eastern	7	1577	1.299 [1.071–1.576]	1.313 [0.973–1.772]		54.8	0.039
Sample size
< 200	5	565	1.320 [0.972–1.792]	1.588 [0.832–3.032]	0.850	75.6	0.003
≥ 200	4	1370	1.530 [1.209–1.742]	1.641 [1.092-2.465]		66.1	0.031
Cut-off value
< 3.0	4	830	1.445 [1.209–1.742]	1.660 [1.048–2.629]	0.697	50.2	0.110
≥ 3.0	5	1105	1.449 [1.144–1.834]	1.511 [0.874–2.612]		79.8	0.001
NOS score
≥ 7	5	1518	1.561 [1.262–1.931]	1.648 [1.183–2.297]		56.0	0.059
< 7	4	417	1.179 [0.824–1.688]	1.576 [0.674–3.688]	0.757	80.0	0.002

ISSN: 1475-2867