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Table 4 Subgroup analysis and Meta regression of pooled HRs for PFS in DLBCL patients with high NLR

From: Prognostic role of neutrophil-to-lymphocyte ratio in diffuse large B cell lymphoma patients: an updated dose–response meta-analysis

Subgroup analysis No. of studies No. of patients Pooled HR (95% CI) Meta regression (p -value) Heterogeneity
Fixed Random I2 (%) p-value
Region
 Western 2 358 3.885 [2.185–6.907] 3.885 [2.185–6.907] 0.027 0 0.926
 Eastern 7 1577 1.299 [1.071–1.576] 1.313 [0.973–1.772]   54.8 0.039
Sample size
 < 200 5 565 1.320 [0.972–1.792] 1.588 [0.832–3.032] 0.850 75.6 0.003
 ≥ 200 4 1370 1.530 [1.209–1.742] 1.641 [1.092-2.465]   66.1 0.031
Cut-off value
 < 3.0 4 830 1.445 [1.209–1.742] 1.660 [1.048–2.629] 0.697 50.2 0.110
 ≥ 3.0 5 1105 1.449 [1.144–1.834] 1.511 [0.874–2.612]   79.8 0.001
NOS score
 ≥ 7 5 1518 1.561 [1.262–1.931] 1.648 [1.183–2.297]   56.0 0.059
 < 7 4 417 1.179 [0.824–1.688] 1.576 [0.674–3.688] 0.757 80.0 0.002
  1. NOS Newcastle–Ottawa Quality Assessment Scale